Wolfgang Löscher Selected Research

GABA-A Receptors (GABA(A) Receptor)

5/2016	Single dose efficacy evaluation of two partial benzodiazepine receptor agonists in photosensitive epilepsy patients: A placebo-controlled pilot study.
1/2014	The pharmacology of imepitoin: the first partial benzodiazepine receptor agonist developed for the treatment of epilepsy.
6/2010	Disease-modifying effects of phenobarbital and the NKCC1 inhibitor bumetanide in the pilocarpine model of temporal lobe epilepsy.
3/2009	New developments in antiepileptic drug resistance: an integrative view.
8/2008	Antiepileptic drug resistant rats differ from drug responsive rats in GABA A receptor subunit expression in a model of temporal lobe epilepsy.
3/2006	Antiepileptic drug-resistant rats differ from drug-responsive rats in hippocampal neurodegeneration and GABA(A) receptor ligand binding in a model of temporal lobe epilepsy.
10/2004	Anticonvulsant efficacy of the low-affinity partial benzodiazepine receptor agonist ELB 138 in a dog seizure model and in epileptic dogs with spontaneously recurrent seizures.
7/2004	The neurobiology of antiepileptic drugs for the treatment of nonepileptic conditions.

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Wolfgang Löscher Research Topics

Disease

137	Epilepsy (Aura) 02/2024 - 01/2002
110	Seizures (Absence Seizure) 01/2024 - 01/2002
47	Status Epilepticus (Complex Partial Status Epilepticus) 01/2023 - 01/2002
44	Temporal Lobe Epilepsy 01/2021 - 01/2002
20	Drug Resistant Epilepsy 01/2022 - 04/2002
14	Brain Diseases (Brain Disorder) 01/2022 - 01/2002
14	Neoplasms (Cancer) 06/2021 - 03/2002
14	Breast Neoplasms (Breast Cancer) 06/2015 - 03/2002
11	Partial Epilepsies (Epilepsy, Partial) 01/2021 - 07/2002
8	Asphyxia (Suffocation) 10/2023 - 01/2021
6	Infections 02/2024 - 08/2005
5	Tuberous Sclerosis (Bourneville's Disease) 02/2024 - 01/2018
5	Brain Injuries (Brain Injury) 10/2021 - 07/2010
5	Nervous System Diseases (Neurological Disorders) 12/2020 - 04/2014
4	Traumatic Brain Injuries (Traumatic Brain Injury) 02/2024 - 12/2010
4	Stroke (Strokes) 02/2024 - 12/2015
4	Migraine Disorders (Migraine) 01/2023 - 07/2004
4	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2022 - 12/2015
3	Cognitive Dysfunction 01/2023 - 11/2016
3	Neuralgia (Stump Neuralgia) 01/2021 - 07/2004
3	Viral Encephalitis 11/2018 - 01/2018
3	Pain (Aches) 06/2017 - 07/2004
2	Generalized Epilepsy 01/2023 - 07/2009
2	Neuroinflammatory Diseases 01/2023 - 12/2016
2	COVID-19 01/2023 - 01/2021
2	Drug-Related Side Effects and Adverse Reactions 01/2022 - 01/2009
2	Polyneuropathies (Polyneuropathy) 01/2022 - 06/2017
2	Glycogen Storage Disease Type II (Pompe's Disease) 12/2021 - 04/2021
2	Critical Illness (Critically Ill) 01/2021 - 12/2016
2	Bipolar Disorder (Manic Depressive Psychosis) 01/2021 - 01/2007

Drug/Important Bio-Agent (IBA)

75	Anticonvulsants (Antiepileptic Drugs)IBA 01/2021 - 01/2002
30	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 01/2022 - 04/2002
30	Kainic Acid (Kainate)IBA 01/2021 - 01/2002
27	Pilocarpine (Ocusert)FDA LinkGeneric 10/2021 - 04/2002
26	Phenobarbital (Luminal)FDA Link 01/2023 - 07/2002
19	Bumetanide (Bumex)FDA LinkGeneric 01/2023 - 06/2010
16	Proteins (Proteins, Gene)FDA Link 01/2020 - 01/2004
13	Phenytoin (Dilantin)FDA LinkGeneric 07/2017 - 09/2002
12	Biomarkers (Surrogate Marker)IBA 02/2024 - 03/2015
12	Levetiracetam (Keppra)FDA LinkGeneric 01/2021 - 04/2002
10	Sodium Potassium Chloride Symporter Inhibitors (Loop Diuretics)IBA 01/2023 - 06/2013
8	GABA-A Receptors (GABA(A) Receptor)IBA 05/2016 - 07/2004
7	Valproic Acid (Depakote)FDA LinkGeneric 07/2017 - 01/2002
7	Pentylenetetrazole (Metrazol)IBA 07/2017 - 10/2008
7	Diazepam (Valium)FDA LinkGeneric 10/2016 - 10/2002
6	Topiramate (Topamax)FDA LinkGeneric 01/2023 - 11/2009
6	BenzodiazepinesIBA 01/2023 - 10/2004
6	LithiumIBA 10/2021 - 10/2009
6	ChloridesIBA 01/2021 - 06/2010
6	gamma-Aminobutyric Acid (GABA)IBA 01/2021 - 07/2002
6	Sodium-Potassium-Chloride SymportersIBA 12/2018 - 02/2014
5	Drug CombinationsIBA 01/2022 - 12/2015
5	Protein Isoforms (Isoforms)IBA 12/2018 - 06/2013
5	AWD 131-138IBA 01/2017 - 10/2004
5	tariquidar (XR9576)IBA 04/2013 - 12/2009
4	salicylhydroxamic acid (SHAM)IBA 10/2023 - 09/2009
4	DiureticsIBA 01/2023 - 02/2014
4	SolutionsIBA 01/2023 - 12/2014
4	Midazolam (Versed)FDA LinkGeneric 01/2023 - 01/2021
4	Mechanistic Target of Rapamycin Complex 1IBA 12/2020 - 01/2018
4	Sirolimus (Rapamycin)FDA Link 12/2020 - 11/2018
4	pqr620IBA 12/2020 - 01/2018
4	Neuroprotective AgentsIBA 01/2019 - 01/2002
4	Isoflurane FDA LinkGeneric 01/2018 - 02/2016
4	Lamotrigine (Lamictal)FDA LinkGeneric 07/2017 - 07/2002
4	Carbamazepine (Tegretol)FDA LinkGeneric 10/2016 - 01/2009
3	azosemideIBA 01/2023 - 01/2021
3	Meglumine FDA Link 01/2023 - 01/2023
3	ezogabine (retigabine)IBA 01/2022 - 01/2002
3	Member 2 Solute Carrier Family 12IBA 01/2022 - 01/2021
3	Aminobutyrates (Aminobutyric Acid)IBA 01/2022 - 01/2021
3	AlbuminsIBA 01/2022 - 01/2018
3	Anti-Anxiety Agents (Anxiolytics)IBA 01/2022 - 01/2014
3	Cholinergic Agents (Cholinergics)IBA 10/2021 - 10/2009
3	CytokinesIBA 01/2021 - 01/2017
3	ProdrugsIBA 01/2021 - 06/2010
3	PQR530IBA 12/2020 - 01/2018
3	trans-sodium crocetinate (crocetin)IBA 12/2020 - 11/2018
3	MTOR InhibitorsIBA 12/2020 - 01/2018
3	AMPA Receptors (AMPA Receptor)IBA 01/2017 - 10/2011
3	multidrug resistance-associated protein 1IBA 10/2013 - 02/2004
3	ElacridarIBA 04/2013 - 04/2011
3	Glutamic Acid (Glutamate)FDA Link 02/2013 - 01/2002
2	nusinersenIBA 04/2024 - 04/2019
2	Torsemide (Demadex)FDA LinkGeneric 01/2023 - 01/2021
2	Rituximab (Mabthera)FDA Link 01/2022 - 03/2019
2	Scopolamine (Hyoscine)FDA Link 10/2021 - 08/2015
2	Felbamate (Felbatol)FDA Link 01/2021 - 07/2002
2	BumepamineIBA 01/2021 - 12/2018
2	Everolimus FDA Link 12/2020 - 01/2018
2	Adenosine Triphosphate (ATP)IBA 12/2020 - 01/2020
2	Phosphotransferases (Kinase)IBA 11/2020 - 09/2015

Therapy/Procedure

58	Therapeutics 06/2023 - 03/2002
14	Drug Therapy (Chemotherapy) 01/2022 - 03/2002
4	Electrodes (Electrode) 01/2021 - 05/2014
3	Injections 01/2023 - 01/2002
2	Precision Medicine 01/2024 - 01/2020
2	Cell Transplantation 01/2023 - 12/2018
2	Home Infusion Therapy 12/2021 - 04/2021
2	Polypharmacy 01/2021 - 03/2015